Alzheimer’s Disease

Lifestyle modifications for prevention

  • A healthy lifestyle that includes: (1)
    • No smoking
    • Avoid high alcohol intake
    • Regular physical activity
    • Healthy eating
    • Normal weight
  • Maintain social activities and interaction and include cognitive or educational activities (2)
  • Intensive risk factor modification may reduce the risk of dementia or prolong time to onset if done no later than 45-65 years of age (2)
  • Exercise alone does not seem to reduce the risk of dementia (2)
  • Cognitive training has uncertain long term effects on cognitive decline (2)
  • Berries high in flavonoids may reduce the risk of dementia (2)
  • Vitamin E supplementation may be effective in slowing progression of mild to moderate Alzheimer (2)
  • Healthy lifestyle: A healthy lifestyle based on smoking status, physical activity level, diet and alcohol consumption is associated with reduced risk of dementia among people with high genetic risk. An unhealthy lifestyle is associated with increased risk of dementia (3)
  • Individualized multidomain intervention: Patients at risk for AD dementia may experience improved cognitive function and reduced AD risk scores through personalized multidomain interventions (4)

References

1) https://bestpractice.bmj.com/topics/en-gb/317/prevention

2) https://www.uptodate.com/contents/prevention-of-dementia

3) https://jamanetwork.com/journals/jama/article-abstract/2738355

4) https://www.sciencedirect.com/science/article/pii/S1552526019353683


Resources

1) Dementia risk calculator

2) https://thebraindocs.com/

3) Can Alzheimers be reversed? Report from an ongoing trial (video)

EXPLANATION TO EVIDENCE PRESENTATION

Figure: Evidence pyramid

Evidence based on guidelines and evidence based Clinical Decision Systems is written in BOLD font

Evidence based on meta analysis or systematic reviews is written in BOLD and CURSIVE font

​Evidence based on randomized controlled trials is written in PLAIN font

Evidence based on observational / cohort studies is written in CURSIVE font